Objective

Denture adhesives are widely used to avoid the detachment and sliding of dentures. However, the adhesion properties can be affected by variation in mouth conditions such as the level of salivation. The objective of this study was to understand the effect of environmental conditions on the adhesion properties of a commercially available denture adhesive named as Poligrip^® Free manufactured by GlaxoSmithKline Ltd., UK and to identify the reasons for the observed variation in its adhesion strength.

Methods

The failure mechanisms of denture adhesive have been assessed through using different physical, mechanical and thermal characterization experiments. All methods were used in different pH, temperatures, and salivation conditions and at the end, a strategy was proposed to overcome the failure of the paste in hyposalivation as well.

Results

In vitro models mimicking the denture gingival interface were designed to evaluate the adhesion properties of the investigated adhesive. Changes in the adhesion strength in response to three major factors related to the oral conditions including level of salivation, pH, and temperature were measured. The results of lap shear, tensile test, and internal interactions suggested a cohesion failure, where the lowest adhesion strength was due to hyposalivation. Fourier transform infrared spectroscopy (FTIR) and rheological analysis confirmed the importance of hydrogen bonds and hydration in the adhesion strength of the paste.

Significance

The investigated scenarios are widely observed in patient using denture adhesives and the clinical reports have indicated the inconsistency in adhesion strength of the commercial products. After identifying the potential reasons for such behavior, methods such as the addition of tripropylene glycol methyl ether (TPME) to enhance internal hydrogen bonds between the polymers are proposed to improve adhesion in the hyposalivation scenario.

中文翻译：

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义齿粘合剂的表征，机理分析和改进的性能

客观的

义齿粘合剂被广泛用于避免义齿的脱落和滑动。但是，粘附性会受到口腔状况（如流涎水平）的变化的影响。这项研究的目的是了解关于命名为Poligrip市售义齿粘合剂的粘合性环境条件的影响^®自由制造由葛兰素史克公司，英国并确定其粘合强度的观察到的变化的原因。

方法

通过使用不同的物理，机械和热特性实验，评估了义齿粘合剂的破坏机理。所有方法都在不同的pH，温度和流涎条件下使用，最后提出了一种克服糊剂在流涎中失败的策略。

结果

设计模拟假牙齿龈界面的体外模型，以评估所研究粘合剂的粘附特性。响应于与口腔状况相关的三个主要因素，包括唾液分泌水平，pH和温度，对粘附强度的变化进行了测量。搭接剪切，拉伸试验和内部相互作用的结果表明内聚力失败，其中最低的粘合强度是由于唾液流涎。傅里叶变换红外光谱（FTIR）和流变学分析证实了氢键和水合在糊料粘合强度中的重要性。

意义

在使用义齿粘合剂的患者中，广泛观察到了所研究的场景，并且临床报告表明，商用产品的粘合强度不一致。在确定这种行为的潜在原因后，提出了一些方法，例如添加三丙二醇甲醚（TPME）以增强聚合物之间的内部氢键，以提高在流涎过程中的附着力。