Mulberry (Morus alba) leaf has been used in Chinese medicine as the remedy for hyperlipidemia and metabolic disorders. Recent report indicated Mulberry leaf extract (MLE) attenuated dyslipidemia and lipid accumulation in high fat diet (HFD)-fed mice. Non-alcoholic fatty liver (NAFLD) is generally considered as the liver component of metabolic syndrome. The hepatic lipid infiltration induces oxidative stress, and is associated with interleukin-6 (IL-6) and tumor necrosis factor-α (TNF-α) which are regulated by the leptin and adiponectin. MLE could prevent obesity-related NAFLD via downregulating the lipogenesis enzymes while upregulating the lipolysis markers. Treatment of MLE, especially at 2%, enhanced the expression of superoxide dismutase (SOD) and clenched the oxidative stress of liver. MLE decreased the plasma level of leptin but increased adiponectin. The advantage of MLE is supposed mainly attributed to chlorogenic acid derivative. We suggest MLE, with promising outcome of research, could be nutraceutical to prevent obesity and related NAFLD.

中文翻译：

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桑叶提取物通过调节脂肪细胞因子、炎症和氧化应激来预防肥胖引起的 NAFLD

桑叶 (Morus alba) 已在中药中用作治疗高脂血症和代谢紊乱的药物。最近的报告表明桑叶提取物 (MLE) 可减轻高脂饮食 (HFD) 喂养小鼠的血脂异常和脂质积累。非酒精性脂肪肝 (NAFLD) 通常被认为是代谢综合征的肝脏成分。肝脏脂质浸润诱导氧化应激，并与受瘦素和脂联素调节的白细胞介素 6 (IL-6) 和肿瘤坏死因子-α (TNF-α) 相关。MLE 可以通过下调脂肪生成酶同时上调脂肪分解标志物来预防肥胖相关的 NAFLD。MLE 的治疗，特别是 2% 的治疗，增强了超氧化物歧化酶 (SOD) 的表达并加强了肝脏的氧化应激。MLE降低了瘦素的血浆水平，但增加了脂联素。MLE的优势主要归功于绿原酸衍生物。我们建议 MLE 具有可喜的研究成果，可作为预防肥胖和相关 NAFLD 的营养品。