Stem cell products and its clinical applications have been widely discussed in recent years, particularly when the Japanese "induced pluripotent stem cells" founder Dr. Yamanaka was awarded as Nobel Prize laureate in 2013. For decades, major progresses have been achieved in the stem cell biology field, and more and more evidence showed that skin stem cells are involved in the process of skin repair. Stem/progenitor cells of the epidermis are recognized to play the most essential role in the tissue regeneration of skin. In this review, we first illustrated basic stem cell characteristics and various stem cell subtypes resided in the skin. Second, we provided several literatures to elucidate how stem/progenitor cells collaborate in the process of skin repair with the evidence from animal model studies and in vitro experiments. Third, we also introduced several examples of skin cell products on the pharmaceutic market and the ongoing clinical trials aiming for unmet medical difficulties of skin. Last but not least, we summarized general reviewing concerns and some disputatious issues on dermatological cell products. With this concise review, we hope to provide further beneficial suggestions for the development of more effective and safer dermatological stem/progenitor cell products in the future.

中文翻译：

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皮肤干细胞治疗：机制、最新进展和药物审查问题

近年来，干细胞产品及其临床应用得到了广泛的讨论，尤其是日本“诱导多能干细胞”创始人山中博士在2013年获得诺贝尔奖时。几十年来，干细胞领域取得了重大进展。生物学领域，越来越多的证据表明皮肤干细胞参与了皮肤修复的过程。表皮的干/祖细胞被认为在皮肤组织再生中起最重要的作用。在这篇综述中，我们首先说明了基本的干细胞特征和存在于皮肤中的各种干细胞亚型。其次，我们提供了几篇文献，以动物模型研究和体外实验的证据阐明干/祖细胞在皮肤修复过程中如何协作。第三，我们还介绍了药物市场上的几个皮肤细胞产品的例子，以及针对未解决的皮肤医学难题正在进行的临床试验。最后但同样重要的是，我们总结了皮肤病细胞产品的一般审查问题和一些有争议的问题。通过这篇简明扼要的综述，我们希望为未来开发更有效、更安全的皮肤科干/祖细胞产品提供进一步的有益建议。