Alzheimer's disease (AD) is marked by several cellular and molecular damage. Therefore, the therapeutic interest of multi-target molecules is increasingly justified. Polyphenols presenting multiple pharmacological effects would be more efficient. In this study, beneficial effects of trans ε-viniferin, a natural polyphenol were thus evaluated. This study reported that this stilbenoid (1) induced the disaggregation of amyloid β (Aβ) peptide and (2) rescued inflammation in murine primary neuronal cultures. These both effects are higher than those of resveratrol, and so, trans ε-viniferin could be a good therapeutic multi-target candidate.

阿尔茨海默氏病（AD）的特征是几种细胞和分子损伤。因此，越来越多地证明了多靶分子的治疗兴趣。呈现多种药理作用的多酚将更为有效。因此，在这项研究中，评估了天然多酚反式ε- viniferin的有益作用。这项研究报告说，这种类胡萝卜素（1）诱导了淀粉样蛋白β（Aβ）肽的分解，并且（2）挽救了小鼠原代神经元培养物中的炎症。这两种作用均高于白藜芦醇，因此，反式ε- viniferin可能是良好的治疗性多靶点候选药物。