Sub-2 μm large-pore monodispersed mesoporous silica spheres (MMSS) were synthesized by using mixed non-ionic surfactants of dodecylamine (DDA) and dodecylamine polyoxyethylene ether (AC1210) as templates through an alkali-catalyzed silica sol–gel technique combined with the template method. Methanol-H₂O volume ratio on morphology was researched in detail. In addition, by using hydrothermal treatment, the average pore size of MMSS could be enlarged to 11 nm from 4.4 nm. The mesoporous silica particles were characterized by scanning electron microscopy (SEM), transmission electron microscopy (TEM), laser particle size analyzer, X-ray diffraction, N₂ physisorption technique. The synthesized sub-2 μm monodispersed mesoporous silica microspheres were successfully functionalized by dimethyloctadecylchlorosilane and used as a packing material in high performance liquid chromatography (HPLC).

通过将十二烷基胺（DDA）和十二烷基胺聚氧乙烯醚（AC1210）的混合非离子表面活性剂作为模板，通过碱催化的二氧化硅溶胶-凝胶技术结合了亚2μm大孔单分散介孔二氧化硅球（MMSS）。模板方法。详细研究了甲醇-H ₂ O体积比对形貌的影响。另外，通过水热处理，MMSS的平均孔径可以从4.4nm扩大到11nm。通过扫描电子显微镜（SEM），透射电子显微镜（TEM），激光粒度分析仪，X射线衍射，N ₂表征介孔二氧化硅颗粒物理吸附技术。合成的亚2μm单分散介孔二氧化硅微球已被二甲基十八烷基氯硅烷成功地官能化，并用作高效液相色谱（HPLC）的填充材料。