Objectives

The aim of the present study was to investigate the surface characteristic, biomechanical behavior, hemocompatibility, bone tissue response and osseointegration of the optimal micro-arc oxidation surface-treated titanium (MST-Ti) dental implant.

Materials and methods

The surface characteristic, biomechanical behavior and hemocompatibility of the MST-Ti dental implant were performed using scanning electron microscope, finite element method, blood dripping and immersion tests. The mini-pig model was utilized to evaluate the bone tissue response and osseointegration of the MST-Ti dental implant in vivo. Data were analyzed by analysis of variance using the Student's t-test (P ≤ 0.05).

Results

The hybrid volcano-like micro/nanoporous structure was formed on the surface of the MST-Ti dental implant. The hybrid volcano-like micro/nanoporous surface played an important role to improve the stress transfer between fixture, cortical bone and cancellous bone for the MST-Ti dental implant. Moreover, the MST-Ti implant was considered to have the outstanding hemocompatibility. In vivo testing results showed that the bone-to-implant contact (BIC) ratio significantly altered as the implant with micro/nanoporous surface. After 12 weeks of implantation, the MST-Ti dental implant group exhibited significantly higher BIC ratio than the untreated dental implant group. In addition, the MST-Ti dental implant group also presented an enhancing osseointegration, particularly in the early stages of bone healing.

Conclusion

It can be concluded that the micro-arc oxidation approach induced the formation of micro/nanoporous surface is a promising and reliable alternative surface modification for Ti dental implant applications.

中文翻译：

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混合的微/纳米结构表面可改善生物医学钛植入物的应力分布并增强骨整合特性

目标

本研究的目的是研究最佳微弧氧化表面处理钛（MST-Ti）牙科植入物的表面特性，生物力学行为，血液相容性，骨组织反应和骨整合。

材料和方法

使用扫描电子显微镜，有限元法，滴血和浸没测试，对MST-Ti牙科植入物的表面特性，生物力学行为和血液相容性进行了测试。微型猪模型用于评估体内MST-Ti牙科植入物的骨组织反应和骨整合。数据通过使用学生方差分析叔测试（P ≤0.05）。

结果

在MST-Ti牙科植入物的表面上形成了混合的火山状微/纳米孔结构。混合火山状的微孔/纳米孔表面对于改善MST-Ti牙科植入物在固定装置，皮质骨和松质骨之间的应力传递起了重要作用。此外，MST-Ti植入物被认为具有出色的血液相容性。体内测试结果表明，随着具有微/纳米孔表面的植入物，骨与植入物的接触（BIC）比率发生了显着变化。植入12周后，MST-Ti牙科植入物组的BIC比明显高于未治疗的牙科植入物组。此外，MST-Ti牙科植入物组还表现出了增强的骨整合性，特别是在骨愈合的早期阶段。

结论

可以得出结论，微弧氧化方法诱导了微/纳米孔表面的形成，是钛牙种植体应用中一种有前途且可靠的替代表面改性方法。