Hepatocellular carcinoma (HCC) chemoresistance, which is regarded as a kind of stress management reaction to chemotherapy drugs, severely hinders the therapy outcomes of HCC treatment. Stress management is generally achieved by activating certain signal pathways and chemical factors, among which, nuclear factor-E2-related factor2 (Nrf2) is a key factor in HCC chemoresistance formation. Nrf2 is a nuclear factor that coordinates the induction and expression of a battery of genes encoding cytoprotective proteins when participating in the Nrf2antioxidant response element (Nrf2/ARE) pathway, which is one of the most important intracellular antioxidant stress pathways. This review summarizes the recent understanding of the involvement of Nrf2 in the chemoresistance of liver cancer, its target proteins, expression regulation and potential Nrf2 inhibitors that sensitize chemotherapy drugs in HCC.

肝细胞癌（HCC）的化学抗性被认为是对化疗药物的一种应激控制反应，严重阻碍了HCC治疗的治疗结果。压力管理通常是通过激活某些信号途径和化学因子来实现的，其中，核因子-E2相关因子2（Nrf2）是肝癌化学抗性形成的关键因素。Nrf2是一种核因子，当参与Nrf2抗氧化反应元件（Nrf2 / ARE）途径时，它是协调一系列编码细胞保护蛋白的基因的诱导和表达的途径，Nrf2 / ARE是最重要的细胞内抗氧化剂应激途径之一。这篇综述总结了对Nrf2参与肝癌化学耐药性，其靶蛋白，