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Chemical analysis of the Alphaproteobacterium strain MOLA1416 associated with the marine lichen Lichina pygmaea
Phytochemistry ( IF 3.2 ) Pub Date : 2018-01-01 , DOI: 10.1016/j.phytochem.2017.10.005
Delphine Parrot , Laurent Intertaglia , Philippe Jehan , Martin Grube , Marcelino T. Suzuki , Sophie Tomasi

Alphaproteobacterium strain MOLA1416, related to Mycoplana ramosa DSM 7292 and Chelativorans intermedius CC-MHSW-5 (93.6% 16S rRNA sequence identity) was isolated from the marine lichen, Lichina pygmaea and its chemical composition was characterized by a metabolomic network analysis using LC-MS/MS data. Twenty-five putative different compounds were revealed using a dereplication workflow based on MS/MS signatures available through GNPS (https://gnps.ucsd.edu/). In total, ten chemical families were highlighted including isocoumarins, macrolactones, erythrinan alkaloids, prodiginines, isoflavones, cyclohexane-diones, sterols, diketopiperazines, amino-acids and most likely glucocorticoids. Among those compounds, two known metabolites (13 and 26) were isolated and structurally identified and metabolite 26 showed a high cytotoxic activity against B16 melanoma cell lines with an IC50 0.6 ± 0.07 μg/mL.

中文翻译:

与海洋地衣 Lichina pygmaea 相关的 Alphaproteobacterium 菌株 MOLA1416 的化学分析

从海洋地衣 Lichina pygmaea 中分离出与 Mycoplana ramosa DSM 7292 和 Chelativorans intermedius CC-MHSW-5(93.6% 16S rRNA 序列同一性)相关的 Alphaproteobacterium 菌株 MOLA1416,并通过使用 LC-MS 的代谢组学网络分析表征其化学成分/MS 数据。使用基于可通过 GNPS (https://gnps.ucsd.edu/) 获得的 MS/MS 特征的去复制工作流程揭示了 25 种推定的不同化合物。总共强调了 10 个化学家族,包括异香豆素、大环内酯、赤藓聚糖生物碱、prodiginines、异黄酮、环己烷二酮、甾醇、二酮哌嗪、氨基酸和最可能的糖皮质激素。在这些化合物中,
更新日期:2018-01-01
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