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Peptide-based biosensors: From self-assembled interfaces to molecular probes in electrochemical assays
Bioelectrochemistry ( IF 4.8 ) Pub Date : 2017-11-23 , DOI: 10.1016/j.bioelechem.2017.11.009
Mihaela Puiu , Camelia Bala

Redox-tagged peptides have emerged as functional materials with multiple applications in the area of sensing and biosensing applications due to their high stability, excellent redox properties and versatility of biomolecular interactions. They allow direct observation of molecular interactions in a wide range of affinity and enzymatic assays and act as electron mediators. Short helical peptides possess the ability to self-assemble in specific configurations with the possibility to develop in highly-ordered, stable 1D, 2D and 3D architectures in a hierarchical controlled manner. We provide here a brief overview of the electrochemical techniques available to study the electron transfer in peptide films with particular interest in developing biosensors with immobilized peptide motifs, for biological and clinical applications.



中文翻译:

基于肽的生物传感器:从自组装界面到电化学测定中的分子探针

带有氧化还原标签的肽由于其高稳定性,出色的氧化还原特性和生物分子相互作用的多功能性,已在传感和生物传感应用领域中成为具有多种应用的功能材料。它们可以在广泛的亲和力和酶法测定中直接观察分子相互作用,并充当电子介体。短螺旋肽具有以特定构型自组装的能力,并有可能以分级受控的方式在高度有序,稳定的1D,2D和3D体系结构中发展。我们在这里提供了可用于研究肽膜中电子转移的电化学技术的简要概述,特别是对于开发具有固定肽基序的生物传感器,以用于生物学和临床应用特别感兴趣。

更新日期:2017-11-23
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