In this paper, we propose a new dynamical model of tissue electroporation. The model is based on equivalent circuit approach at the tissue. Considering two current densities from cells and extracellular matrix, we identify the macroscopic homogenised contribution of the cell membranes. Our approach makes it possible to define a macroscopic homogenised electric field and a macroscopic homogenised transmembrane potential. This provides a direct link between the cell scale electroporation models and the tissue models. Finite element method adapted to the new non-linear model of tissue electroporation is used to compare experiments with simulations. Adapting the phenomenological electroporation model of Leguèbe et al. to the tissue scale, we calibrate the tissue model with experimental data. This makes two steps appear in the tissue electroporation process, as for cells. The new insight of the model lies in the well-established equivalent circuit approach to provide a homogenised version of cell scale models. Our approach is tightly linked to numerical homogenisation strategies adapted to bioelectrical tissue modeling.

在本文中，我们提出了一种新的组织电穿孔动力学模型。该模型基于组织处的等效电路方法。考虑到来自细胞和细胞外基质的两种电流密度，我们确定了细胞膜的宏观均质化贡献。我们的方法能够定义一个宏观均质电场和宏观均质跨膜电位。这提供了细胞规模电穿孔模型和组织模型之间的直接联系。适应新的组织电穿孔非线性模型的有限元方法用于比较实验和仿真。适应Leguèbe等人的现象学电穿孔模型。根据组织规模，我们用实验数据校准组织模型。对于细胞，这使两个步骤出现在组织电穿孔过程中。该模型的新见解在于完善的等效电路方法，可提供单元规模模型的均质化版本。我们的方法与适用于生物电组织模型的数值均质化策略紧密相关。