The syntheses of three platinum(II) complexes bearing sulfonamide-((E)-2-(4-methylphenylsulfonamido)-2′,6′-difluoroazobenzene, HL1) and hydroxy-azo-2,6-difluorobenzene ((E)-2-((2,6-difluorophenyl)diazenyl)phenol, HL2) bidentate ligands is described. These complexes, [Pt(L1)(DMSO)Cl] (1), [Pt(L2)(DMSO)Cl] (2), and [Pt(L2)₂] (3), were characterized by multinuclear NMR spectroscopy, mass spectrometry, and X-ray crystallography. Despite bearing azobenzene functional groups, none of the three complexes undergo photoisomerization. The anticancer activities of these complexes were evaluated in wild-type (A2780) and cisplatin-resistant (A2780CP70) ovarian cancer cells. All three complexes exhibited IC₅₀ values below 10 μM and displayed similar activity in both A2780 and A2780CP70 cell lines, indicating that they are not cross-resistant with cisplatin. The DNA-binding properties of 1–3 were investigated by circular dichroism spectroscopy and by agarose gel electrophoresis. Both studies suggest that 1 and 2 form monofunctional DNA adducts.

带有磺酰胺-（（E）-2-（4-甲基苯基磺酰胺基）-2'，6'-二氟偶氮苯HL1和羟基-偶氮-2,6-二氟苯（（E）-描述了2-（（2，6-二氟苯基）二氮烯基）苯酚，HL2）双齿配体。这些络合物[Pt（L1）（DMSO）Cl]（1），[Pt（L2）（DMSO）Cl]（2）和[Pt（L2）₂ ]（3用多核NMR光谱，质谱和X射线晶体学进行表征。尽管带有偶氮苯官能团，这三种络合物均未进行光异构化。在野生型（A2780）和顺铂耐药（A2780CP70）卵巢癌细胞中评估了这些复合物的抗癌活性。这三种复合物在A2780和A2780CP70细胞系中均表现出低于10μM的IC ₅₀值，并显示出相似的活性，表明它们与顺铂没有交叉耐药性。的DNA结合性质1 - 3通过圆二色光谱，并通过琼脂糖凝胶电泳进行了调查。两项研究均表明1和2 形成单功能DNA加合物。