Abstract Owing to the excellent self-assembly properties and chemical flexibility, amyloid peptide were employed to build multifunctional architectures. Herein, we demonstrated the self-assembly of gold nanoparticles (AuNPs) in assistant of a sequence-designed peptide. As both surface ligands and self-assembly scaffolds of AuNPs, the formation of amyloid peptide nanofibrils could drive the self-assembly of AuNPs to form a fibrous hybrid architecture, which exhibits excellent electrochemical and colorimetric sensing performances. As a result, the electrochemical sensing towards H 2 O 2 achieved a linear response range of from 0.1 to 25.85 mM (R 2 = 0.997), and the detection limit was calculated to be 3.43 μM (S/N = 3). This self-assembled nanofiber was also employed for Hg 2+ detection. The sensor produced a color change which can readout with naked eye and UV–visual spectroscopy, with a linear detection range of 10–70 μM of Hg 2+ ion sample (R 2 = 0.991).

中文翻译：

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基于自组装肽-金纳米纤维结构的电化学和比色传感器的绿色合成和制造

摘要 由于优异的自组装性能和化学灵活性，淀粉样肽被用于构建多功能结构。在此，我们展示了在序列设计的肽的辅助下金纳米粒子 (AuNPs) 的自组装。作为AuNPs的表面配体和自组装支架，淀粉样肽纳米纤维的形成可以驱动AuNPs的自组装形成纤维混合结构，表现出优异的电化学和比色传感性能。结果，对H 2 O 2 的电化学传感实现了0.1 至25.85 mM (R 2 = 0.997) 的线性响应范围，计算出检测限为3.43 μM (S/N = 3)。这种自组装纳米纤维也用于 Hg 2+ 检测。