Abstract A robust copper-based metal-organic framework (MOF) catalyst, termed MOF-891, was successful applied to the synthesis of the family of bioactive compounds, bis(indolyl)methanes, through a Friedel–Crafts alkylation under ultrasound irradiation. The remarkable catalytic activity of MOF-891 was proven by the successful synthesis of bis(indolyl)methanes in high yield (up to 96%) and purity. In MOF-891, there exist two types of copper clusters, one discrete and one infinite rod, both are formed through water molecules triggering hydrogen bonds demonstrated the participation as catalytic active site for the Friedel–Crafts alkylation reaction. The well-defined construction of hydrogen bonds in MOF-891 along with Lewis copper sites attributed a stable catalysis activity and exhibited the heterogeneous nature with no significant loss of catalytic performance after six cycles.

中文翻译：

---

一种高活性铜基金属有机骨架催化剂，用于在超声辐照下合成双（吲哚基）甲烷中的 Friedel-Crafts 烷基化反应

摘要 一种坚固的铜基金属有机骨架 (MOF) 催化剂，称为 MOF-891，通过在超声辐照下的 Friedel-Crafts 烷基化成功地应用于合成生物活性化合物家族，双（吲哚基）甲烷。MOF-891 的显着催化活性通过以高产率（高达 96%）和纯度成功合成双（吲哚基）甲烷证明。在 MOF-891 中，存在两种类型的铜簇，一种是离散的，一种是无限的，都是通过水分子触发氢键形成的，这表明作为 Friedel-Crafts 烷基化反应的催化活性位点参与其中。