Abstract We here report the synthesis of novel chalcone-sulfonamide compounds based on the hybridization at 2′ position and nitro substitution at the side chalcone phenyl ring followed by tandem cyclization into quinolinone derivatives and then a further aldol condensation only as a function of the reaction time. Therefore, for the first time, we have controlled the sequential preparation of chalcone-sulfonamide hybrids, quinolinones and then ( E )-3-ene-2,3-dihydroquinolinones simply stopping reaction over increasing time periods. Furthermore, a new molecular scaffold based on a chalcone-(bis)sulfonamide hybrid has been gotten through changing the sequence of coupling reactions and catalyst. This study means practical and useful ways of constructing in high yields new biologically active compounds bearing diversified molecular scaffolds.

中文翻译：

---

串联查尔酮-磺酰胺杂化、环化和进一步的 Claisen-Schmidt 缩合：通过反应时间、顺序和催化剂调节分子多样性

摘要 我们在此报告了基于 2' 位杂交和侧查尔酮苯环上的硝基取代，然后串联环化成喹啉酮衍生物，然后仅作为反应时间函数的进一步羟醛缩合的新型查尔酮磺酰胺化合物的合成。 . 因此，我们第一次控制了查尔酮-磺酰胺杂化物、喹啉酮和 (E)-3-烯-2,3-二氢喹啉酮的顺序制备，在增加的时间段内简单地停止反应。此外，通过改变偶联反应和催化剂的顺序，获得了一种基于查耳酮-（双）磺酰胺杂化物的新型分子支架。这项研究意味着以高产率构建具有多样化分子支架的新型生物活性化合物的实用和有用的方法。