Towards safe therapy for immunodeficiency

Towards safe therapy for immunodeficiency, Published online: 12 December 2017; doi:10.1038/s41551-017-0174-x

A humanized mouse model of X-linked severe combined immunodeficiency suggests that the safety of correcting the human IL2RG gene in haematopoietic stem cells depends on both gene-correction frequency and the conditioning regimen used before cell transplantation.

中文翻译：

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寻求针对免疫缺陷的安全疗法

寻求针对免疫缺陷的安全疗法

迈向免疫缺陷的安全疗法，在线发布：2017年12月12日；doi：10.1038 / s41551-017-0174-x

X连锁严重联合免疫缺陷的人源化小鼠模型提示，在造血干细胞中纠正人IL2RG基因的安全性取决于基因纠正频率和细胞移植前使用的条件疗法。