Naturally occurring heterocycles such as pyrones, dihydropyrones, and isocoumarins have proven to be highly active biological agents with a vast plethora of applications. Therefore, their synthesis has attracted mentionable notice in recent decades. Of particular synthetic use is the cyclization of substituted alkynyl esters. More recently, main group compounds have been studied to affect this synthetic pathway giving access to a large family of heterocyclic derivatives.

中文翻译：

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取代的炔基酯、醚和酸的现代环化方法的比较评估

天然存在的杂环如吡喃酮、二氢吡喃酮和异香豆素已被证明是具有大量应用的高活性生物制剂。因此，它们的合成在近几十年来引起了人们的注意。特别的合成用途是取代炔基酯的环化。最近，已经研究了主要组化合物以影响该合成途径，从而获得一大类杂环衍生物。