Neurodegenerative disorders such as Alzheimer’s, Parkinson’s, and Huntington’s diseases are highly prevalent and immensely destructive to the health and well-being of individuals and their families across the globe. Neurodegenerative diseases are characterized by the gradual loss of neural tissue in the central nervous system. Clearly, early diagnosis of the onset of neurodegeneration is vital and beneficial. Current diagnostic methods rely heavily on symptoms or autopsy results, thus overlooking early diagnosis, the only opportunity for amelioration. However, appropriately selected and used biomarker diagnostics provide a solution. This article reviews the development and application of biomarker-related diagnostics for neurodegenerative disease with specific recommendations for point-of-care (POC) methodology. These advantageous approaches may offer a solution to existing obstacles and limitations to neurodegenerative disease treatment.

诸如阿尔茨海默氏症，帕金森氏症和亨廷顿氏病等神经退行性疾病非常普遍，对全球的个人及其家庭的健康和福祉具有极大的破坏性。神经退行性疾病的特征在于中枢神经系统中神经组织的逐渐丧失。显然，早期诊断神经退行性疾病至关重要且有益。当前的诊断方法严重依赖于症状或尸检结果，因此忽视了早期诊断，这是改善的唯一机会。然而，适当地选择使用的生物标志物的诊断提供了一种解决方案。本文回顾了针对神经退行性疾病的生物标志物相关诊断方法的开发和应用，并提出了针对即时医疗点（POC）方法的具体建议。