Objectives To determine the risk of uveitis and inflammatory bowel disease (IBD) in patients with psoriatic arthritis (PsA) compared with the general population and patients with psoriasis. Methods A cohort study using data from the UK Clinical Practice Research Datalink between 1998 and 2014. Patients with incident PsA aged 18–89 years were identified and matched to a cohort of patients with psoriasis and a general population cohort. The incidence of uveitis, all IBD, Crohn’s disease and ulcerative colitis was calculated for each study cohort and adjusted relative risks (RRadj) were calculated using conditional Poisson regression. Results 6783 incident cases of PsA were identified with a median age of 49 years. The risk of uveitis was significantly higher in the PsA cohort than in the general population and psoriasis cohorts (RRadj 3.55, 95% CI 2.21 to 5.70 and RRadj 2.13, 95% CI 1.40 to 3.24, respectively). A significant increase was observed for Crohn’s disease (RRadj 2.96, 95% CI 1.46 to 6.00 and RRadj3.60, 95% CI 1.83 to 7.10) but not for ulcerative colitis (RRadj1.30, 95% CI 0.66 to 2.56 and RRadj0.98, 95% CI 0.50 to 1.92). Conclusions In a primary care-based incidence cohort of patients with PsA, there were substantial risks of developing uveitis and/or Crohn’s disease, but not ulcerative colitis, when compared with the general population and psoriasis controls.

中文翻译：

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银屑病关节炎患者葡萄膜炎和炎症性肠病的风险：一项基于人群的队列研究

目的 确定银屑病关节炎 (PsA) 患者与普通人群和银屑病患者相比发生葡萄膜炎和炎症性肠病 (IBD) 的风险。方法 使用 1998 年至 2014 年间来自英国临床实践研究数据链的数据进行的队列研究。确定了 18-89 岁的 PsA 患者，并将其与银屑病患者队列和一般人群队列相匹配。计算每个研究队列的葡萄膜炎、所有 IBD、克罗恩病和溃疡性结肠炎的发生率，并使用条件泊松回归计算调整后的相对风险 (RRadj)。结果 6783 例 PsA 事件被确定，中位年龄为 49 岁。PsA 队列的葡萄膜炎风险显着高于普通人群和银屑病队列（RRadj 3.55, 95% CI 2. 21 至 5.70 和 RRadj 2.13，95% CI 1.40 至 3.24，分别）。观察到克罗恩病显着增加（RRadj 2.96, 95% CI 1.46 至 6.00 和 RRadj3.60, 95% CI 1.83 至 7.10）但溃疡性结肠炎未观察到（RRadj1.30, 95% CI 0.66 至 2.56 和 RRadj0.98 , 95% CI 0.50 至 1.92)。结论 在基于初级保健的 PsA 患者发病率队列中，与普通人群和银屑病对照组相比，发生葡萄膜炎和/或克罗恩病的风险很大，但溃疡性结肠炎的风险不大。