This article examines the increasing importance of dried matrix spot (DMS) specimens (such as dried blood spots, dried urine spots, etc.) in biomedical research, the challenges associated with their analysis when quantitative elemental information is aimed at, as well as the benefits deriving from the further usage of these types of samples. The article briefly reviews the historical evolution of this sampling approach in elemental clinical analysis, stressing prospective areas of applications (e.g., newborns or prosthesis control), the methodologies most recently developed to produce DMS of known volume, as well as novel strategies proposed to analyze them, often related to direct solid sampling techniques or fast lixiviation methods. Finally, the article discusses the type of information that could be obtained after isotopic analysis of DMS when targeting non-traditional stable isotopes (e.g., Cu, Fe or Zn), which can significantly help in the early diagnosis of some medical conditions (e.g. Wilson's disease).

本文探讨了干基质斑点（DMS）标本（例如干血斑，干尿斑等）在生物医学研究中的重要性日益提高，针对定量元素信息进行分析时面临的挑战以及这些类型的样本的进一步使用带来了很多好处。本文简要回顾了这种采样方法在基本临床分析中的历史沿革，强调了潜在的应用领域（例如，新生儿或假体控制），最近开发的用于生产已知体积DMS的方法以及提议用于分析的新策略它们通常与直接固体采样技术或快速浸提法有关。最后，