Sea cucumber saponin liposomes ameliorate obesity-induced inflammation and insulin resistance in high-fat-diet-fed mice,Food & Function

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Sea cucumber saponin liposomes ameliorate obesity-induced inflammation and insulin resistance in high-fat-diet-fed mice
Food & Function ( IF 5.1 ) Pub Date : 2017-12-11 00:00:00 , DOI: 10.1039/c7fo01599b
Cheng Chen _{1,

2,

3,

4} , Xiuqing Han _{1,

2,

3,

4} , Ping Dong _{1,

2,

3,

4} , Zhaojie Li _{1,

2,

3,

4} , Teruyoshi Yanagita _{5,

6,

7,

8} , Changhu Xue _{1,

2,

3,

4,

9} , Tiantian Zhang _{1,

2,

3,

4} , Yuming Wang _{1,

2,

3,

4,

9}

Affiliation

Obesity has become a worldwide concern in recent years, which may cause many diseases. Much attention has been paid to food components that are considered to be beneficial in preventing chronic metabolic diseases. The present study was conducted to investigate the effects of sea cucumber saponin liposomes on certain metabolic markers associated with obesity. C57/BL6 mice fed with high-fat diet were treated with different forms of sea cucumber saponins for eight weeks. The results showed that liposomes exhibited better effects on anti-obesity and anti-hyperlipidemia activities than the common form of sea cucumber saponins. Sea cucumber saponin liposomes could also effectively alleviate adipose tissue inflammation by reducing pro-inflammatory cytokine releases and macrophage infiltration. Moreover, sea cucumber saponin liposomes improved insulin resistance by altering the uptake and utilization of glucose. Taken together, our results indicated that the intake of sea cucumber saponin liposomes might be able to ameliorate obesity-induced inflammation and insulin resistance.

中文翻译：

海参皂苷脂质体改善肥胖引起的高脂饮食小鼠的炎症和胰岛素抵抗

肥胖是近年来引起全世界关注的问题，它可能引起许多疾病。人们对被认为对预防慢性代谢性疾病有益的食品成分给予了极大关注。进行本研究以研究海参皂苷脂质体对某些与肥胖有关的代谢标志物的影响。高脂饮食喂养的C57 / BL6小鼠用不同形式的海参皂苷处理了八周。结果表明，脂质体比普通形式的海参皂苷具有更好的抗肥胖和高脂血症作用。海参皂苷脂质体还可以通过减少促炎性细胞因子的释放和巨噬细胞浸润来有效减轻脂肪组织的炎症。而且，海参皂苷脂质体通过改变葡萄糖的吸收和利用来改善胰岛素抵抗。两者合计，我们的结果表明，摄入海参皂苷脂质体可能能够改善肥胖引起的炎症和胰岛素抵抗。

更新日期：2017-12-11

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