Cocrystal structure design for CH5134731 based on isomorphism†,CrystEngComm

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Cocrystal structure design for CH5134731 based on isomorphism†
CrystEngComm ( IF 2.6 ) Pub Date : 2017-12-11 00:00:00 , DOI: 10.1039/c7ce01878a
S. Tanida _{1,

2,

3,

4} , N. Takata _{1,

2,

3,

4} , R. Takano _{1,

2,

3,

4} , A. Sakon _{1,

2,

3,

4} , T. Ueto _{1,

2,

3,

4} , K. Shiraki _{1,

2,

3,

4} , K. Kadota _{4,

5,

6} , Y. Tozuka _{4,

5,

6} , M. Ishigai _{1,

2,

3,

4}

Affiliation

We succeeded in forming a benzoic acid cocrystal of CH5134731 by focusing on the isomorphism shown by its solvates. As a result of evaluation, the benzoic acid cocrystal showed good solubility. This crystal engineering approach made it possible to reduce the amount of compound and study time in the early stage of research and development.

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