The link between GBM molecular subtype and response to treatment remains undefined. In this issue of Cancer Cell, Cosset and colleagues define a subpopulation of patients within the proneural/classical subtype sensitive to integrin blockade because of a Glut3 addiction. These findings reveal context-dependent druggable vulnerability in a subpopulation of GBM.

中文翻译：

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Glut3成瘾：胶质母细胞瘤中的可药物性脆弱性。

GBM分子亚型与治疗反应之间的联系仍然不确定。在本期《癌细胞》中，Cosset和同事定义了由于Glut3上瘾而对整联蛋白阻断敏感的前/经典亚型内的患者亚群。这些发现揭示了GBM亚群中与情境相关的可药物治疗的脆弱性。