Bone metastases are incurable. The bone microenvironment has always been a suspect for this clinical enigma, but the exact mechanisms have been unclear. In this issue of Cancer Cell, Zheng and colleagues provide evidence that chemotherapy itself induces chemoresistance of bone metastases, mediated by osteoblast Jagged1-induced tumor Notch signaling.

中文翻译：

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打破化学抗药性的障碍：化学诱导成骨细胞锯齿状的作用1。

骨转移是无法治愈的。骨微环境一直是该临床谜团的可疑对象，但确切的机制尚不清楚。在本期《癌细胞》中，Zheng及其同事提供了证据，表明化学疗法本身可诱导成骨细胞Jagged1诱导的肿瘤Notch信号传导介导的骨转移的化学耐药性。