Abstract Here we present the microfluidic approach to engineer polymeric Janus particles using solvent dissolution for potential drug delivery applications. Unlike the polymerization based particle generation techniques, this method does not suffer from potential toxicity concerns for drug delivery. This technique is based on dissolving away the solvent in the solution droplets containing designed concentration distribution of drug and polymer while preserving the concentration distribution during the transition of the droplet into a particle. We investigated the kinetics of solidification and concentration evolution in the droplets under different operational conditions. Our investigation demonstrated that the designed biphasic concentration of a drug surrogate introduced into two hemispheres of the droplets can be preserved in solidified particles. We conclude with practical guidelines for generating polymeric Janus particles using the dissolution technique.

中文翻译：

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使用微流体溶剂溶解方法设计用于药物递送的聚合物 Janus 粒子

摘要 在这里，我们介绍了使用溶剂溶解来设计聚合物 Janus 粒子的微流体方法，用于潜在的药物递送应用。与基于聚合的粒子生成技术不同，该方法不会受到药物递送的潜在毒性问题的影响。该技术基于溶解掉包含设计的药物和聚合物浓度分布的溶液液滴中的溶剂，同时在液滴转变为颗粒的过程中保持浓度分布。我们研究了不同操作条件下液滴的凝固动力学和浓度演变。我们的研究表明，引入液滴的两个半球的药物替代物的设计双相浓度可以保留在固化颗粒中。我们总结了使用溶解技术生成聚合物 Janus 颗粒的实用指南。