pH-Activated nanoparticles with targeting for the treatment of oral plaque biofilm†,Journal of Materials Chemistry B

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pH-Activated nanoparticles with targeting for the treatment of oral plaque biofilm†
Journal of Materials Chemistry B ( IF 6.1 ) Pub Date : 2017-12-11 00:00:00 , DOI: 10.1039/c7tb02682j
Zhongzheng Zhou _{1,

2,

3,

4} , Fang Hu _{4,

5,

6,

7} , Shihao Hu _{1,

2,

3,

4} , Ming Kong _{1,

2,

3,

4} , Chao Feng _{1,

2,

3,

4} , Ya Liu _{1,

2,

3,

4} , Xiaojie Cheng _{1,

2,

3,

4} , Qiuxia Ji _{4,

5,

6,

7} , Xiguang Chen _{1,

2,

3,

4,

8}

Affiliation

Oral plaque biofilms are highly resilient microbial assemblies that are challenging to eradicate. Herein, we describe the synthesis and study of pH-positive, doxycycline (DOX)-loaded nanocarriers to combat pathogenic biofilms. The mixed shell–core nanoparticles consisted of quaternary ammonium chitosan (TMC) as a positively charged section, which targeted nanoparticles to negatively charged biofilm surfaces. In addition liposomes were used as a DOX loading tool to eradicate the multidrug-resistant biofilm. In a drug release test, DOX release was pH-dependent with t_1/2 = 0.75 h and 2.3 h for release at pH 4.5 and 6.8, respectively. Furthermore, TMC–Lip–DOX NPs could adhere to the biofilm and efficiently remove the biofilm from the hydroxyapatite (HA) surface. Furthermore, TMC–Lip–DOX NPs had biocomaptible properties and were non-toxic to MC3T3-E1 cells. This constitutes a highly effective pathway to control oral plaque biofilms and has a good potential use for dental biofilm therapies.

中文翻译：

pH活化的纳米颗粒具有靶向性，可用于治疗口腔菌斑生物膜†

口腔菌斑生物膜是具有高弹性的微生物组件，很难根除。在这里，我们描述了合成和研究pH值，强力霉素（DOX）负载纳米载体对抗病原性生物膜。混合的壳核纳米颗粒由季铵壳聚糖（TMC）组成，带正电荷，将纳米颗粒靶向带负电荷的生物膜表面。此外，脂质体还用作DOX加载工具，以根除耐多药的生物膜。在药物释放测试中，DOX释放是pH依赖性的，t _1/2分别在pH 4.5和6.8下释放0.75 h和2.3 h。此外，TMC–Lip–DOX NP可以粘附在生物膜上，并有效地从羟基磷灰石（HA）表面去除生物膜。此外，TMC–Lip–DOX NP具有生物适应性，并且对MC3T3-E1细胞无毒。这构成了控制口腔斑块生物膜的高效途径，并且在牙科生物膜治疗中具有良好的潜在用途。

更新日期：2017-12-11

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