Cancer immunotherapy has received considerable attention because of a variety of exciting clinical outcomes in recent years. At the interface of cancer immunotherapy and bioengineering, there are many opportunities to further improve the treatment efficacy or address current challenges in immunotherapy. Cellular bioparticulates as promising carriers of immunomodulators have attracted much attention due to their inherent biocompatibility and unique biological properties. This Topical Review highlights recently reported studies utilizing bioparticulates for cancer immunotherapy, including engineered red blood cells (RBC) and RBC membrane coated particles, engineered T-cells, engineered platelets, and engineered microbes.

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细胞生物微粒与癌症免疫疗法的治疗方法

近年来，由于各种令人兴奋的临床结果，癌症免疫疗法受到了广泛的关注。在癌症免疫治疗和生物工程学的接口上，有许多机会可以进一步提高治疗功效或解决免疫治疗方面的当前挑战。由于其固有的生物相容性和独特的生物学特性，作为免疫调节剂的有希望的载体的细胞生物颗粒引起了人们的广泛关注。本专题综述重点介绍了最近报道的利用生物微粒进行癌症免疫治疗的研究，包括工程红细胞（RBC）和RBC膜包被的颗粒，工程T细胞，工程血小板和工程微生物。