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Visible‐Light‐Promoted Alkylation of Indoles with Tertiary Amines by the Oxidation of a sp3 C‐H Bond
Advanced Synthesis & Catalysis ( IF 5.4 ) Pub Date : 2017-12-18 , DOI: 10.1002/adsc.201701131
Xuan Ding 1 , Chun-Lin Dong 1 , Zhi Guan 1 , Yan-Hong He 1
Affiliation  

A visible‐light driven reaction for the synthesis of 3‐arylmethyl indole derivatives using tertiary amines and indoles was first reported. Corresponding products were obtained with yields of up to 70%, and various functional groups on the indoles were well tolerated when Rose Bengal was used as a photosensitizer and air was used as a green oxidant under mild reaction conditions.

中文翻译:

通过sp3 C-H键的氧化在可见光下促进叔胺与吲哚的烷基化

首次报道了使用叔胺和吲哚合成可见光驱动的3-芳基甲基吲哚衍生物的反应。当在温和的反应条件下,将玫瑰红用作光敏剂,并将空气用作绿色氧化剂时,可获得相应的产物,收率高达70%,并且吲哚上的各种官能团均具有良好的耐受性。
更新日期:2017-12-18
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