The precise control of both the size and shape of Ag nanoparticles strongly influences their optical properties. Although the synthesis of Ag nanocubes with sharp corners and edges has been demonstrated, the ability to scale these approaches with high selectivity remains elusive. In this study, a continuous flow microwave-assisted reactor was used to separate nucleation from growth events, which provides a method to synthesize very uniform single crystalline Ag nanocubes. Nucleation in the microwave zone was enhanced through seed-mediated processes by sulfide formation, and a chemical regulator was used in the growth zone to further improve the sharpness of the edges of the nanocubes. Transmission electron microscopy and optical properties were used to optimize the reaction conditions and Ag nanocubes with edge lengths of 28 and 45 nm were readily synthesized with narrow particle size distributions and high selectivities (>70%). Nanocubes with 28 nm edge lengths were used to prepare films to demonstrate the detection of Rhodamine 6G with concentrations down to 10 nM using surface enhanced Raman spectroscopy. These results indicate that continuous flow approaches have the potential to produce large quantities of uniform Ag nanocubes that can be used for sensing or other applications.

中文翻译：

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连续合成单分散银纳米粒子

Ag纳米颗粒的尺寸和形状的精确控制强烈地影响了它们的光学性能。尽管已经证明了具有尖角和边缘的Ag纳米立方体的合成，但是以高选择性缩放这些方法的能力仍然难以捉摸。在这项研究中，使用连续流微波辅助反应器将成核与生长事件分开，这为合成非常均匀的单晶Ag纳米立方体提供了一种方法。通过种子介导的过程通过硫化物的形成增强了微波区域中的成核作用，并且在生长区域中使用了化学调节剂来进一步提高纳米立方体边缘的清晰度。使用透射电子显微镜和光学性质来优化反应条件，并且可以容易地合成具有窄的粒度分布和高的选择性（> 70％）的边缘长度分别为28和45 nm的Ag纳米立方体。边缘长度为28 nm的纳米立方体被用于制备薄膜，以证明使用表面增强拉曼光谱技术可检测低至10 nM浓度的若丹明6G。这些结果表明，连续流动方法具有产生大量可用于传感或其他应用的均匀银纳米立方体的潜力。边缘长度为28 nm的纳米立方体被用于制备薄膜，以证明使用表面增强拉曼光谱技术可检测低至10 nM浓度的若丹明6G。这些结果表明，连续流动方法具有产生大量可用于传感或其他应用的均匀银纳米立方体的潜力。边缘长度为28 nm的纳米立方体被用于制备薄膜，以证明使用表面增强拉曼光谱技术可检测低至10 nM浓度的若丹明6G。这些结果表明，连续流动方法具有产生大量可用于传感或其他应用的均匀银纳米立方体的潜力。