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Bioactive polyoxygenated seco-cyclohexenes from Artabotrys hongkongensis
Bioorganic Chemistry ( IF 4.5 ) Pub Date : 2017-12-07 , DOI: 10.1016/j.bioorg.2017.12.011 Yan-Ping Liu , Jin-Ying Tang , Yan Hua , Liang Lai , Xiu-Lan Luo , Zhi-Jie Zhang , Wen-Qing Yin , Guang-Ying Chen , Yan-Hui Fu
更新日期：2017-12-07
Bioorganic Chemistry ( IF 4.5 ) Pub Date : 2017-12-07 , DOI: 10.1016/j.bioorg.2017.12.011 Yan-Ping Liu , Jin-Ying Tang , Yan Hua , Liang Lai , Xiu-Lan Luo , Zhi-Jie Zhang , Wen-Qing Yin , Guang-Ying Chen , Yan-Hui Fu
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Six new polyoxygenated seco-cyclohexenes, artahongkongenes A–F (1–6), together with six known analogues (7–12) were isolated from the stems and leaves of Artabotrys hongkongensis. Their structures were elucidated by extensive spectroscopic methods. All new compounds were evaluated for their cytotoxicities against five human cancer cell lines: HL-60, SMMC-7721, A-549, MCF-7 and SW480 in vitro. New seco-cyclohexenes 1–6 showed significant inhibitory effects against various human cancer cell lines with IC50 values ranging from 0.26 to 16.58 μM.
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