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Chicken breast muscle hydrolysates ameliorate acute alcohol-induced liver injury in mice through alcohol dehydrogenase (ADH) activation and oxidative stress reduction†
Food & Function ( IF 5.1 ) Pub Date : 2017-12-08 00:00:00 , DOI: 10.1039/c7fo01387f Chuqiao Xiao 1, 2, 3, 4, 5 , Feibai Zhou 1, 2, 3, 4, 5 , Mouming Zhao 1, 2, 3, 4, 5 , Guowan Su 1, 2, 3, 4, 5 , Baoguo Sun 1, 2, 3, 4, 6
Food & Function ( IF 5.1 ) Pub Date : 2017-12-08 00:00:00 , DOI: 10.1039/c7fo01387f Chuqiao Xiao 1, 2, 3, 4, 5 , Feibai Zhou 1, 2, 3, 4, 5 , Mouming Zhao 1, 2, 3, 4, 5 , Guowan Su 1, 2, 3, 4, 5 , Baoguo Sun 1, 2, 3, 4, 6
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In this study, the ameliorative effect of chicken breast muscle hydrolysates (CBMHs) against acute alcohol-induced liver injury was investigated and its probable mechanism was further elucidated. In vitro studies clearly showed that CBMHs are able to activate alcohol metabolic enzymes (i.e. alcohol dehydrogenase, ADH) in an exponential manner. Meanwhile, an in vivo experiment on male NIH mice indicated that the oral administration of CBMHs (150, 300 and 600 mg per kg bw) 30 min prior to acute alcohol ingestion could significantly promote alcohol metabolism as revealed by the reduced duration of the loss of righting reflex (LORR) and the enhanced activity of alcohol dehydrogenase (ADH) and aldehyde dehydrogenase (ALDH) in the liver, the latter accelerating alcohol oxidation and therefore the decreased blood alcohol concentration (BAC) level. Pretreatment with CBMHs significantly decreased the elevations of serum aspartate transaminase (AST) and alanine transaminase (ALT) after alcohol administration. CBMHs could also retard lipid peroxidation as revealed by the suppressed malondialdehyde (MDA) level and simultaneously enhance the activities of superoxide dismutase (SOD) in liver tissue. Furthermore, increased histological damage and higher (p < 0.05) hepatic triglyceride (TG) contents in acute alcoholic-diet fed mice were also reduced (p < 0.05) by supplementing with CBMHs. These benefits clearly suggested that CBMHs could be a potential nutraceutical to facilitate alcohol metabolism and prevent or ameliorate early liver injury induced by acute alcohol exposure.
中文翻译：
鸡胸肌水解物可通过乙醇脱氢酶（ADH）活化和氧化应激降低来减轻小鼠急性酒精性肝损伤†
在这项研究中，研究了鸡胸肌水解产物（CBMHs）对急性酒精引起的肝损伤的改善作用，并进一步阐明了其可能的机制。体外研究清楚地表明，CBMHs能够以指数方式激活酒精代谢酶（即酒精脱氢酶，ADH）。同时，体内对雄性NIH小鼠进行的实验表明，急性酒精摄入前30分钟口服CBMH（150、300和600 mg / kg bw）可以显着促进酒精代谢，如正直反射丧失（LORR）的持续时间缩短以及肝脏中酒精脱氢酶（ADH）和醛脱氢酶（ALDH）的活性增强，后者会加速酒精氧化，从而降低血液中酒精浓度（BAC）的水平。服用酒精后，用CBMHs预处理可显着降低血清天冬氨酸转氨酶（AST）和丙氨酸转氨酶（ALT）的升高。如抑制的丙二醛（MDA）水平所揭示的那样，CBMHs还可以延缓脂质过氧化，并同时增强肝脏组织中的超氧化物歧化酶（SOD）的活性。此外，p在急性酒精饮食喂养的小鼠<0.05）肝甘油三酯（TG）含量也被减少（p通过与CBMHs补充<0.05）。这些好处清楚地表明，CBMHs可能是一种潜在的营养保健品，可促进酒精代谢并预防或减轻急性酒精暴露引起的早期肝损伤。
更新日期：2017-12-08
中文翻译：
鸡胸肌水解物可通过乙醇脱氢酶（ADH）活化和氧化应激降低来减轻小鼠急性酒精性肝损伤†
在这项研究中，研究了鸡胸肌水解产物（CBMHs）对急性酒精引起的肝损伤的改善作用，并进一步阐明了其可能的机制。体外研究清楚地表明，CBMHs能够以指数方式激活酒精代谢酶（即酒精脱氢酶，ADH）。同时，体内对雄性NIH小鼠进行的实验表明，急性酒精摄入前30分钟口服CBMH（150、300和600 mg / kg bw）可以显着促进酒精代谢，如正直反射丧失（LORR）的持续时间缩短以及肝脏中酒精脱氢酶（ADH）和醛脱氢酶（ALDH）的活性增强，后者会加速酒精氧化，从而降低血液中酒精浓度（BAC）的水平。服用酒精后，用CBMHs预处理可显着降低血清天冬氨酸转氨酶（AST）和丙氨酸转氨酶（ALT）的升高。如抑制的丙二醛（MDA）水平所揭示的那样，CBMHs还可以延缓脂质过氧化，并同时增强肝脏组织中的超氧化物歧化酶（SOD）的活性。此外，p在急性酒精饮食喂养的小鼠<0.05）肝甘油三酯（TG）含量也被减少（p通过与CBMHs补充<0.05）。这些好处清楚地表明，CBMHs可能是一种潜在的营养保健品，可促进酒精代谢并预防或减轻急性酒精暴露引起的早期肝损伤。
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