The understanding of migraine pathophysiology is advancing rapidly. Improved characterisation and diagnosis of its clinical features have led to the view of migraine as a complex, variable disorder of nervous system function rather than simply a vascular headache. Recent studies have provided important new insights into its genetic causes, anatomical and physiological features, and pharmacological mechanisms. The identification of new migraine-associated genes, the visualisation of brain regions that are activated at the earliest stages of a migraine attack, a greater appreciation of the potential role of the cervical nerves, and the recognition of the crucial role for neuropeptides are among the advances that have led to novel targets for migraine therapy. Future management of migraine will have the capacity to tailor treatments based on the distinct mechanisms of migraine that affect individual patients.

中文翻译：

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偏头痛的病理生理学：对临床管理的影响。

对偏头痛病理生理学的理解正在迅速发展。改善其临床特征的表征和诊断已导致偏头痛被视为一种复杂的，可变的神经系统功能障碍，而不仅仅是血管性头痛。最近的研究为其遗传原因，解剖和生理特征以及药理机制提供了重要的新见解。新的偏头痛相关基因的鉴定，偏头痛发作的最早阶段被激活的大脑区域的可视化，对颈神经潜在作用的更大理解以及对神经肽的关键作用的认识都包括在内。导致偏头痛治疗新目标的进展。