Replication fork reversal is a rapidly emerging and remarkably frequent mechanism of fork stabilization in response to genotoxic insults. Here, we summarize recent findings that uncover key molecular determinants for reversed fork formation and describe how the homologous recombination factors BRCA1, BRCA2, and RAD51 protect these structures from extended nucleolytic degradation.

中文翻译：

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复制叉逆转：玩家和守护者

复制叉逆转是响应遗传毒性侮辱而快速稳定出现的叉稳定机制。在这里，我们总结了最近的发现，这些发现揭示了反向叉形成的关键分子决定因素，并描述了同源重组因子BRCA1，BRCA2和RAD51如何保护这些结构免于延长的核酸降解。