Links between oncogenic drivers and cancer cell metabolism have emerged over the past several decades, indicating that constitutive oncogenic growth signaling can render cancers susceptible to metabolic interventions. While significant progress has been achieved in the identification of metabolic vulnerabilities of cancer cells, the complexity of the tumor microenvironment (TME) and the dynamic nature of organismal circadian metabolism challenge the precision of targeting cancer metabolism. Here current progress in the areas of cancer metabolism and TME metabolism is reviewed, highlighting how cancer metabolism can be accurately and precisely targeted.

中文翻译：

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精确准确地利用癌症的代谢脆弱性

在过去的几十年里，致癌驱动因素和癌细胞代谢之间的联系已经出现，表明组成型致癌生长信号可以使癌症容易受到代谢干预的影响。虽然在识别癌细胞的代谢脆弱性方面取得了重大进展，但肿瘤微环境（TME）的复杂性和生物昼夜代谢的动态性质对靶向癌症代谢的精度提出了挑战。本文回顾了癌症代谢和 TME 代谢领域的最新进展，重点介绍了如何准确、精准地靶向癌症代谢。