Mammalian tissue development is an intricate, spatiotemporal process of self-organization that emerges from gene regulatory networks of differentiating stem cells. A major goal in stem cell biology is to gain a sufficient understanding of gene regulatory networks and cell–cell interactions to enable the reliable and robust engineering of morphogenesis. Here, we review advances in synthetic biology, single cell genomics, and multiscale modeling, which, when synthesized, provide a framework to achieve the ambitious goal of programming morphogenesis in complex tissues and organoids.

中文翻译：

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通过系统和合成生物学编程形态发生

哺乳动物组织的发育是一个复杂的，自组织的时空过程，它是由分化干细胞的基因调控网络产生的。干细胞生物学的一个主要目标是对基因调节网络和细胞间的相互作用有足够的了解，以实现可靠而健壮的形态发生工程。在这里，我们回顾了合成生物学，单细胞基因组学和多尺度建模的进展，这些进展在合成后提供了实现在复杂组织和类器官中编程形态发生的宏伟目标的框架。