A spirocyclic, sp³-atom rich oxetane-containing scaffold was synthesised in just two steps via a gold catalysed propargylic alcohol rearrangement. The key gold cyclisation can be undertaken on a 40 g scale allowing the preparation of 419 lead-like compounds based on the scaffold for the European Lead Factory.

中文翻译：

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功能强大的螺环氧杂环丁烷-哌啶骨架用于药物发现

经由金催化的炔丙醇重排仅两步合成了螺环，富含sp ³原子的氧杂环丁烷。关键的金环化反应可以40 g规模进行，从而可以基于欧洲铅厂的支架制备419种铅状化合物。