Neuromicrobiology: How Microbes Influence the Brain,ACS Chemical Neuroscience

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Neuromicrobiology: How Microbes Influence the Brain
ACS Chemical Neuroscience ( IF 4.1 ) Pub Date : 2017-12-28 00:00:00 , DOI: 10.1021/acschemneuro.7b00373
Cesar de la Fuente-Nunez _{1,

2,

3,

4,

5} , Beatriz Torres Meneguetti ₆ , Octávio Luiz Franco _{6,

7} , Timothy K. Lu _{1,

2,

3,

4,

5}

Affiliation

We review here recent discoveries in the exciting new field of neuromicrobiology. This field encompasses the interactions between the microbiome and the central nervous system. The microbiome has a tremendous impact on human health. In particular, the gut microbiota may play a key role in many essential processes in health and disease via the activity of the gut-brain axis, possibly contributing to autism spectrum disorders, Alzheimer’s disease, Parkinson’s disease, depression, and anxiety disorder. Gut microbes may also be involved in nociception, complex host behaviors, and brain development. Future efforts will be needed to determine whether the observed associations correspond to causative mechanisms, as well as to engineer effective interventions to modulate the effects of the microbiome on the central nervous system.

中文翻译：

神经微生物学：微生物如何影响大脑

我们在这里回顾神经微生物学新领域的最新发现。该领域涵盖了微生物组和中枢神经系统之间的相互作用。微生物组对人类健康具有巨大影响。尤其是，肠道菌群可能通过肠脑轴的活动在健康和疾病的许多重要过程中发挥关键作用，可能导致自闭症谱系障碍，阿尔茨海默氏病，帕金森氏症，抑郁症和焦虑症。肠道微生物也可能参与伤害感受，复杂的宿主行为和大脑发育。将需要进一步的努力来确定所观察到的关联是否与致病机制相对应，并需要进行有效的干预以调节微生物组对中枢神经系统的影响。

更新日期：2017-12-28

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