A Brønsted acid-promoted asymmetric intramolecular allylic amination of alcohols†,Organic & Biomolecular Chemistry

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A Brønsted acid-promoted asymmetric intramolecular allylic amination of alcohols†
Organic & Biomolecular Chemistry ( IF 2.9 ) Pub Date : 2017-12-07 00:00:00 , DOI: 10.1039/c7ob02599h
Jianqiao Zhou _{1,

2,

3,

4,

5} , Hexin Xie _{1,

2,

3,

4,

5}

Affiliation

Reported herein is a chiral Brønsted acid-catalyzed asymmetric intramolecular allylic amination reaction, allowing facile access to a range of biologically interesting chiral 2-substituted hydroquinolines in up to 90% yield and with up to 93% ee. Furthermore, a significant effect of an N-protecting group was observed in this asymmetric process.

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