Nanoparticles of metal–organic cages designed to encapsulate platinum-based anticancer agents†,Dalton Transactions

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Nanoparticles of metal–organic cages designed to encapsulate platinum-based anticancer agents†
Dalton Transactions ( IF 4 ) Pub Date : 2017-12-07 00:00:00 , DOI: 10.1039/c7dt03537c
Zhizhou Yue _{1,

2,

3,

4} , Han Wang _{1,

2,

3,

4} , David J. Bowers _{1,

2,

3,

4} , Min Gao _{2,

3,

4,

5,

6} , Morgan Stilgenbauer _{1,

2,

3,

4} , Frederick Nielsen _{1,

2,

3,

4} , Jacob T. Shelley _{7,

8,

9,

10,

11} , Yao-Rong Zheng _{1,

2,

3,

4}

Affiliation

We present a novel design to use metal–organic cages (MOCs) to encapsulate Pt-based anticancer agents for delivery. A fluorescein-conjugated Pt(IV) prodrug of cisplatin is developed for its encapsulation in a cationic MOC via host–guest interactions, which then forms drug-loaded nanoparticles with an anionic polymer.

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