Polθ helicase: drive or reverse

Polθ helicase: drive or reverse, Published online: 07 December 2017; doi:10.1038/nsmb.3510

The helicase intrinsic to DNA polymerase θ (Polθ), the versatile mediator of microhomology-based repair of DNA double-strand breaks and stalled replication forks, is now revealed to be a member of an elite group of proteins known as annealing helicases. This small family of enzymes remodels DNA intermediates in multiple repair processes that are crucial to preserving genome stability and warding off cancer and aging.

中文翻译：

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Polθ解旋酶：驱动或反向

Polθ解旋酶：驱动或反向

Polθ解旋酶：正向或反向，在线发布：2017年12月7日；doi：10.1038 / nsmb.3510

DNA聚合酶θ（Polθ）固有的解旋酶是基于微同源性修复DNA双链断裂和停滞的复制叉的多功能介体，现已发现是称为退火解旋酶的蛋白质精英群的成员。这个小家族的酶在多种修复过程中重塑DNA中间体，这对于保持基因组稳定性以及抵御癌症和衰老至关重要。