Poly(A) tails: longer is not always better

Poly(A) tails: longer is not always better, Published online: 07 December 2017; doi:10.1038/nsmb.3509

Deadenylation of mRNAs is generally associated with translational inhibition and mRNA decay. A study now reports that, unexpectedly, highly expressed genes tend to have shorter poly(A) tails and suggests that poly(A) tails can be 'pruned', generating a 30-nucleotide-biased phased distribution, likely due to protection by poly(A)-binding proteins.

中文翻译：

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Poly（A）尾巴：更长并不总是更好

Poly（A）尾巴：更长并不总是更好

Poly（A）的尾巴：更长并不总是更好，在线发布：2017年12月7日；doi：10.1038 / nsmb.3509

mRNA的腺苷酸化通常与翻译抑制和mRNA衰变有关。一项研究现在报告，出乎意料的是，高表达基因倾向于具有较短的poly（A）尾巴，并表明poly（A）尾巴可以被“修剪”，产生30个核苷酸偏向的相态分布，这可能是由于poly（A）的保护所致。 （A）结合蛋白。