Tumor progression and resistance to treatment are often accompanied by the polarization of malignant cells towards a mesenchymal or poorly differentiated state. Such a transition generates an accrued vulnerability to the induction of ferroptosis, potentially paving the way to novel therapeutic strategies for targeting residual disease in patients with cancer.

中文翻译：

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用铁与抗性癌症作斗争

肿瘤的进展和对治疗的抵抗力通常伴随着恶性细胞向间充质或低分化状态的分化。这种转变会导致易患铁线虫病，从而为针对癌症患者残余疾病的新型治疗策略铺平了道路。