Background

Obesity is a serious health problem and the cause for social and economic burdens. Currently, there is still no cure for obesity, while the investment of time and money for one is huge. Recent years, the possibility of developing natural products from fruits and vegetables with bioactivities into anti-disease agents has become a hot spot in research. Thus, anthocyanins are increasingly causing more attention, as they have been proved to show anti-obesity effects. Furthermore, recent advances in biosynthesis of anthocyanins in microorganisms have illustrated a promising way in producing these valuable compounds in large scales.

Scope and approach

Anthocyanins have great importance in developing a cure for obesity and biosynthesis in microorganisms has high potential in their massive production. This review therefore highlights the recent advances in the anti-obesity effects of anthocyanins and their biosynthesis in microorganisms. We have comprehensively discussed the molecular mechanisms involved in the anti-obesity effects of anthocyanins, the physicochemical and physiological properties of anthocyanins, the suitability of anthocyanins in anti-obesity therapies as well as the possibility of biosynthesis in microorganisms in future application.

Key findings and conclusions

Anthocyanins have shown anti-obesity effects through multiple mechanisms, and biosynthesis of anthocyanins in microorganisms could have extensive applications. Inhibiting lipid absorption, regulating lipid metabolism, increasing energy expenditure, suppressing food intake and regulating gut microbiota are major mechanisms involved. Moreover, anthocyanins are promising candidates in developing anti-obesity therapies. Further studies are required to explore therapeutic uses of anthocyanins in treating obesity and application of biosynthesis of anthocyanins in microorganisms in industries.

中文翻译：

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在了解花色苷的抗肥胖活性及其在微生物中的生物合成方面的最新进展

背景

肥胖是一个严重的健康问题，是造成社会和经济负担的原因。当前，仍然没有治愈肥胖症的方法，而一个人的时间和金钱的投资是巨大的。近年来，将具有生物活性的水果和蔬菜中的天然产物开发成抗疾病剂的可能性已经成为研究的热点。因此，花青素已被证明具有抗肥胖作用，因此越来越引起人们的关注。此外，微生物中花色苷生物合成的最新进展说明了大规模生产这些有价值的化合物的有前途的方法。

范围和方法

花色苷在开发肥胖症的治疗方法中非常重要，微生物的生物合成在其大规模生产中具有很高的潜力。因此，本综述强调了花色素苷的抗肥胖作用及其在微生物中的生物合成的最新进展。我们已经全面讨论了花色素苷抗肥胖作用的分子机制，花色素苷的理化和生理特性，花色素苷在抗肥胖症治疗中的适用性以及微生物在未来应用中生物合成的可能性。

主要发现和结论

花青素通过多种机理显示出抗肥胖作用，微生物中花青素的生物合成可能具有广泛的应用。抑制脂质吸收，调节脂质代谢，增加能量消耗，抑制食物摄入和调节肠道菌群是主要的机制。此外，花青素是开发抗肥胖疗法的有前途的候选者。需要进一步的研究来探索花青素在肥胖症中的治疗用途以及在工业微生物中花青素的生物合成应用。