Bibenzyl-Based Meroterpenoid Enantiomers from the Chinese Liverwort Radula sumatrana,Journal of Natural Products

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Bibenzyl-Based Meroterpenoid Enantiomers from the Chinese Liverwort Radula sumatrana
Journal of Natural Products ( IF 3.3 ) Pub Date : 2017-12-07 00:00:00 , DOI: 10.1021/acs.jnatprod.7b00394
Xiao Wang ₁ , Lin Li ₁ , Rongxiu Zhu ₂ , Jiaozhen Zhang ₁ , Jinchuan Zhou ₁ , Hongxiang Lou ₁

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Six new pairs of bibenzyl-based meroterpenoid enantiomers, (±)-rasumatranin A–D (1–4) and (±)-radulanin M and N (5 and 6), and six known compounds were isolated from the adnascent Chinese liverwort, Radula sumatrana. Their structures were elucidated based on spectroscopic data and chiral phase HPLC-ECD analyses. The structures of 1 and 7 were also confirmed by single-crystal X-ray diffraction analysis. Cytotoxicity tests of the isolated compounds showed that 6-hydroxy-3-methyl-8-phenylethylbenzo[b]oxepin-5-one (8) showed activity against the human cancer cell lines MCF-7, PC-3, and SMMC-7721, with IC₅₀ values of 3.86, 6.60, and 3.58 μM, respectively, and induced MCF-7 cell death through a mitochondria-mediated apoptosis pathway.

更新日期：2017-12-07

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