Cover Feature: Methyl Fumarate‐Derived Iron Carbonyl Complexes (FumET‐CORMs) as Powerful Anti‐inflammatory Agents (ChemMedChem 23/2017),ChemMedChem

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Cover Feature: Methyl Fumarate‐Derived Iron Carbonyl Complexes (FumET‐CORMs) as Powerful Anti‐inflammatory Agents (ChemMedChem 23/2017)
ChemMedChem ( IF 3.6 ) Pub Date : 2017-12-07 , DOI: 10.1002/cmdc.201700736
Britta Bauer ₁ , Anna-Lena Göderz ₂ , Heidi Braumüller ₁ , Jörg Martin Neudörfl ₂ , Martin Röcken ₁ , Thomas Wieder ₁ , Hans-Günther Schmalz ₂

Affiliation

The Cover Feature shows the “championship” of anti‐inflammatory agents for dendritic cells. The winners are FumET‐CORMs which were developed by fusing a methyl fumarate and an enzyme‐triggered carbon monoxide releasing molecule (ET‐CORM). The intracellular activation of the FumET‐CORMs by an esterase leads to the simultaneous release of CO and methyl fumarate. In contrast to the clinically used dimethyl fumarate or CO alone, the strong cellular response of dendritc cells towards FumET‐CORMs reflects the synergetic action of the two agents as indicated by the suppression of secretion of inflammatory interleukins IL‐12 and IL‐23. More information can be found in the Communication by Thomas Wieder, Hans‐Günther Schmalz et al. on page 1927 in Issue 23, 2017 (DOI: 10.1002/cmdc.201700488).

中文翻译：

封面功能：富马酸甲酯衍生的铁羰基复合物（FumET-CORM）作为有效的抗炎药（ChemMedChem 23/2017）

封面功能显示了针对树突状细胞的抗炎剂的“冠军”。获奖者是FumET-CORM，它是通过将富马酸甲酯和酶触发的一氧化碳释放分子（ET-CORM）融合而开发的。酯酶在细胞内激活FumET-CORMs导致同时释放CO和富马酸甲酯。与临床上单独使用的富马酸二甲酯或CO相比，树突状细胞对FumET-CORM的强烈细胞反应反映了两种药物的协同作用，如炎症性白介素IL-12和IL-23分泌的抑制所表明的。可以在Hans-GüntherSchmalz等人的Thomas Wieder的通讯中找到更多信息。就在第23期，2017年1927年页（：10.1002 / cmdc.201700488 DOI）。

更新日期：2017-12-07

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