Photocontrolled Release of Chemicals from Nano‐ and Microparticle Containers,Angewandte Chemie International Edition

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Photocontrolled Release of Chemicals from Nano‐ and Microparticle Containers
Angewandte Chemie International Edition ( IF 16.1 ) Pub Date : 2018-01-16 , DOI: 10.1002/anie.201710756
Christoph Englert _{1,

2} , Ivo Nischang _{1,

2} , Cornelia Bader _{1,

2} , Philipp Borchers _{1,

2} , Julien Alex _{1,

2} , Michael Pröhl _{1,

2} , Martin Hentschel ₃ , Matthias Hartlieb _{1,

2,

4} , Anja Traeger _{1,

2} , Georg Pohnert _{2,

5} , Stephanie Schubert _{2,

6} , Michael Gottschaldt _{1,

2} , Ulrich S. Schubert _{1,

2}

Affiliation

A benzoin‐derived diol linker was synthesized and used to generate biocompatible polyesters that can be fully decomposed on demand upon UV irradiation. Extensive structural optimization of the linker unit was performed to enable the defined encapsulation of diverse organic compounds in the polymeric structures and allow for a well‐controllable polymer cleavage process. Selective tracking of the release kinetics of encapsulated model compounds from the polymeric nano‐ and microparticle containers was performed by confocal laser scanning microscopy in a proof‐of‐principle study. The physicochemical properties of the incorporated and released model compounds ranged from fully hydrophilic to fully hydrophobic. The demonstrated biocompatibility of the utilized polyesters and degradation products enables their use in advanced applications, for example, for the smart packaging of UV‐sensitive pharmaceuticals, nutritional components, or even in the area of spatially selective self‐healing processes.

中文翻译：

从纳米和微粒容器中光化学释放化学物质

合成了由苯偶姻衍生的二醇连接基，并用于生成生物相容性聚酯，该聚酯可根据需要在紫外线照射下完全分解。对连接单元进行了广泛的结构优化，以实现聚合物结构中各种有机化合物的确定包封，并实现了可控的聚合物裂解过程。在原理证明研究中，通过共聚焦激光扫描显微镜对聚合物纳米和微粒容器中包封的模型化合物的释放动力学进行了选择性追踪。掺入和释放的模型化合物的物理化学性质从完全亲水到完全疏水。所利用的聚酯和降解产物的生物相容性得到证明，使其可用于高级应用，例如，

更新日期：2018-01-16

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