Palladium (Pd) is widely used in chemistry, biology, environmental science etc., and Pd²⁺ is the most plenitudinous oxidation state of the Pd that can exist under physiological conditions or in living cells, which could have adverse effects on both our health and environment. Thus, it is of great significance to monitor the changes of Pd²⁺. Hence, a novel near-infrared fluorescent probe M-PD has been developed for selective detection of Pd²⁺ based on naphthofluorescein in this work. The result demonstrated that M-PD exhibited favorable properties for sensing Pd²⁺ such as excellent water solubility, high selectivity and sensitivity. And the limit of detection was estimated as 10.8 nM, much lower than the threshold in drugs (5–10 ppm) specified by European Directorate for the Quality Control of Medicines. More importantly, detection and recovery experiments of Pd²⁺ in aspirin aqoeous solution and soil are satisfactory. In addition, M-PD has also been successfully used for near-infrared fluorescence imaging of Pd²⁺ in living cells, indicating that the probe has better feasibility and application potential in the determination of Pd²⁺.

钯（Pd）广泛用于化学，生物学，环境科学等领域，Pd ²⁺是在生理条件下或活细胞中可能存在的Pd最丰富的氧化态，可能对我们的健康产生不利影响和环境。因此，监测Pd ²⁺的变化具有重要意义。因此，在这项工作中，已经开发出一种新颖的近红外荧光探针M-PD用于基于萘荧光素的Pd ²⁺的选择性检测。结果表明，M-PD表现出良好的感测Pd ^2+的性能。如优异的水溶性，高选择性和灵敏度。并且检测限估计为10.8 nM，远低于欧洲药品质量控制局指定的药物阈值（5-10 ppm）。更重要的是，在阿司匹林水溶液和土壤中对Pd ^2+的检测和回收实验令人满意。此外，M-PD也已成功用于活细胞中Pd ^2+的近红外荧光成像，表明该探针在测定Pd ²⁺方面具有更好的可行性和应用潜力。