Open globe injuries are full-thickness injuries sustained to the eye wall (cornea or sclera), which cause immediate drops in intraocular pressure that may lead to retinal detachment and permanent vision loss if not treated rapidly after injury. The current standard of care for open globe injuries consists of suturing the margins closed, but the technique can be time-consuming, requires specialized training and equipment, and can lead to patient discomfort, abrasion, and infection from eye rubbing. We engineered an injectable, thermoresponsive sealant (TRS) and a custom tool to occlude open globe injuries. The smart hydrogel sealant consists of physically cross-linked N-isopropylacrylamide copolymerized with butylacrylate. At low temperatures, it can be injected as a liquid, and when raised to body temperature, a heat-induced gelation converts the hydrogel into a solidified occlusion. The sealant can be repositioned or removed without causing additional trauma via exposure to cold water. In vitro and ex vivo assessments of mechanical adhesion to eye tissue revealed maintenance of intraocular pressure that is five times greater than the physiological range with reversible seal strength comparable to cyanoacrylate (super glue). In vivo assessment in a rabbit model of ocular trauma demonstrated ease of use for TRS deployment, statistically significant improvement in wound sealing, and no evidence of neurotoxicity, retinal tissue degradation, or significant chronic inflammatory response after 30 days of exposure. Given the advantages of body heat–induced gelation, rapid reversible occlusion, and in vivo safety and efficacy, shape-adaptable TRSs have translational potential as smart wound sealants for temporary occlusion of surgical incisions or traumatic injuries.

开放性眼球损伤是指眼壁（角膜或巩膜）遭受的全层损伤，如果不及时治疗，会导致眼内压立即下降，从而可能导致视网膜脱离和永久性视力丧失。当前针对开放性眼球受伤的护理标准包括缝合闭合的切缘，但该技术可能很耗时，需要专门的培训和设备，并且可能导致患者不适，磨损和因揉眼而引起感染。我们设计了一种可注射的热响应性密封剂（TRS）和一种自定义工具来遮挡裸露的地球仪伤害。智能水凝胶密封剂由物理交联的N组成-异丙基丙烯酰胺与丙烯酸丁酯共聚。在低温下，它可以以液体形式注射，当升至体温时，热诱导的凝胶化作用将水凝胶转化为凝固的闭塞物。密封剂可以重新放置或移除，而不会因暴露于冷水而造成额外的伤害。体外和离体对眼组织机械粘附的评估显示，眼内压维持比生理范围大五倍，可逆密封强度可与氰基丙烯酸酯（超级胶）相媲美。在兔眼外伤模型中进行的体内评估表明，TRS部署易于使用，在伤口密封方面具有统计学上的显着改善，并且在暴露30天后没有神经毒性，视网膜组织降解或明显的慢性炎症反应的证据。