Fabrication of Defined Polydopamine Nanostructures by DNA Origami-Templated Polymerization.,Angewandte Chemie International Edition

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Fabrication of Defined Polydopamine Nanostructures by DNA Origami-Templated Polymerization.
Angewandte Chemie International Edition ( IF 16.1 ) Pub Date : 2018-01-15 , DOI: 10.1002/anie.201711560
Yu Tokura _{1,

2} , Sean Harvey ₁ , Chaojian Chen _{1,

2} , Yuzhou Wu _{1,

3} , David Y W Ng ₁ , Tanja Weil _{1,

2}

Affiliation

A versatile, bottom-up approach allows the controlled fabrication of polydopamine (PD) nanostructures on DNA origami. PD is a biosynthetic polymer that has been investigated as an adhesive and promising surface coating material. However, the control of dopamine polymerization is challenged by the multistage-mediated reaction mechanism and diverse chemical structures in PD. DNA origami decorated with multiple horseradish peroxidase-mimicking DNAzyme motifs was used to control the shape and size of PD formation with nanometer resolution. These fabricated PD nanostructures can serve as "supramolecular glue" for controlling DNA origami conformations. Facile liberation of the PD nanostructures from the DNA origami templates has been achieved in acidic medium. This presented DNA origami-controlled polymerization of a highly crosslinked polymer provides a unique access towards anisotropic PD architectures with distinct shapes that were retained even in the absence of the DNA origami template.

中文翻译：

通过 DNA 折纸模板聚合制备确定的聚多巴胺纳米结构。

一种多功能、自下而上的方法允许在 DNA 折纸上可控地制造聚多巴胺 (PD) 纳米结构。 PD 是一种生物合成聚合物，已被研究作为粘合剂和有前途的表面涂层材料。然而，多巴胺聚合的控制受到多阶段介导的反应机制和多巴胺化学结构的挑战。用多个模仿辣根过氧化物酶的 DNAzyme 基序装饰的 DNA 折纸被用来以纳米分辨率控制 PD 形成的形状和大小。这些制造的PD纳米结构可以作为“超分子胶”来控制DNA折纸构象。在酸性介质中已经实现了从 DNA 折纸模板中轻松释放 PD 纳米结构。这种高度交联聚合物的 DNA 折纸控制聚合提供了一种独特的方法来获得各向异性的 PD 结构，即使在没有 DNA 折纸模板的情况下，这些结构也能保留不同的形状。

更新日期：2018-01-15

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