Multicompartment Vesicles Formation by Emulsification‐Induced Assembly of Poly(ethylene oxide)‐block‐poly(ε‐caprolactone) and Their Dual‐Loading Capability,Macromolecular Rapid Communications

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Multicompartment Vesicles Formation by Emulsification‐Induced Assembly of Poly(ethylene oxide)‐block‐poly(ε‐caprolactone) and Their Dual‐Loading Capability
Macromolecular Rapid Communications ( IF 4.2 ) Pub Date : 2017-12-06 , DOI: 10.1002/marc.201700545
Seon-Mi Jin ₁ , Jongseol Jeon ₁ , Mi-Kyoung Park ₁ , Geon Hee Kim ₂ , Eunji Lee ₁

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Emulsification‐induced assembly is employed to allow structural diversity in nanoaggregates of a biocompatible amphiphilic polymer, poly(ethylene oxide)‐block‐poly(ε‐caprolactone). Onion‐like vesicles are efficiently produced by tuning the interfacial instability of the oil‐in‐water emulsion. The increase in the polymer concentration and use of the organic solvents with a low interfacial tension between water and the oil phase lead to a strong tendency of emulsion droplets to generate the onion‐like vesicles. The vesicular networks and fibers are also obtained by controlling the concentration and type of the surfactant, respectively. Interestingly, the onion‐like vesicles composed of alternating walls and water channels and the vesicular networks originated from a string of vesicles show dual‐loading ability for hydrophobic and hydrophilic dyes but slightly different loading capacities. This result indicates that the development of a methodology to fabricate well‐defined, unique nanostructures, such as multivesicular and multilamellar nanostructures, and subsequent elucidation of their structure–property relationships can provide useful guidance in the design of novel biomedical materials.

中文翻译：

聚（环氧乙烷）-嵌段-聚（ε-己内酯）的乳化诱导组装形成多室囊泡及其双重负载能力

乳化诱导组装用于使生物相容性两亲性聚合物（聚环氧乙烷）嵌段的纳米聚集体具有结构多样性-聚（ε-己内酯）。通过调节水包油乳液的界面不稳定性，可以有效地产生洋葱状的囊泡。聚合物浓度的增加和水与油相之间界面张力低的有机溶剂的使用导致乳液液滴产生洋葱状囊泡的强烈趋势。还分别通过控制表面活性剂的浓度和类型来获得囊泡网络和纤维。有趣的是，由交替的壁和水通道组成的洋葱状囊泡和源自一串囊泡的囊泡网络对疏水性和亲水性染料显示出双重负载能力，但负载能力略有不同。该结果表明，开发了定义明确的独特纳米结构的方法，

更新日期：2017-12-06

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