Reaction-Based Fluorescent Probes for the Imaging of Nitroxyl (HNO) in Biological Systems,ACS Chemical Biology

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Reaction-Based Fluorescent Probes for the Imaging of Nitroxyl (HNO) in Biological Systems
ACS Chemical Biology ( IF 3.5 ) Pub Date : 2017-12-06 00:00:00 , DOI: 10.1021/acschembio.7b00901
Baoli Dong ₁ , Xiuqi Kong ₁ , Weiying Lin ₁

Affiliation

Nitroxyl (HNO) has been identified as an important signaling molecule in biological systems and plays critical roles in many physiological processes. Fluorescence imaging could provide a robust approach to explore the biological formation of HNO and its physiological functions. Herein, we summarize the organic reaction types for constructing HNO probes and specifically focus on review of the recent advances in the development of the reaction-based HNO probes and their imaging applications in living systems.

中文翻译：

基于反应的荧光探针在生物系统中对硝基（HNO）的成像

硝基氧（HNO）已被确定为生物系统中的重要信号分子，并在许多生理过程中起着至关重要的作用。荧光成像可以提供一种鲁棒的方法来探索HNO的生物学形成及其生理功能。在本文中，我们总结了用于构建HNO探针的有机反应类型，并特别关注于基于反应的HNO探针的开发及其在生物系统中的成像应用的最新进展。

更新日期：2017-12-06

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